Cargando…

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

OBJECTIVE: Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet β-cells by promoting growth and survival. IRS-2 turnover is rapid in primary β-cells, but its expression is highly regulated at the transcriptional level, especially by glucose. The aim was to investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Demozay, Damien, Tsunekawa, Shin, Briaud, Isabelle, Shah, Ramila, Rhodes, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198104/ https://www.ncbi.nlm.nih.gov/pubmed/21940781 http://dx.doi.org/10.2337/db11-0341

Ejemplares similares

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes
por: Tsunekawa, Shin, et al.
Publicado: (2011)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure
por: Hodik, M, et al.
Publicado: (2016)

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
por: Mezza, Teresa, et al.
Publicado: (2014)

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
por: Rosario, Wilfredo, et al.
Publicado: (2016)

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet
por: Syed, Ismail, et al.
Publicado: (2011)

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
por: Molina, Judith, et al.
Publicado: (2014)

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
por: Bone, Robert N., et al.
Publicado: (2015)

Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
por: Ding, Guo-Lian, et al.
Publicado: (2012)

Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)–calcineurin–NFAT signaling
por: Li, Huiming, et al.
Publicado: (2012)

The role of Ca(2+)/Calcineurin/NFAT signalling pathway in osteoblastogenesis
por: Ren, Ranyue, et al.
Publicado: (2021)

SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion
por: Chen, Zheng, et al.
Publicado: (2014)

Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass
por: Nguidjoe, Evrard, et al.
Publicado: (2011)

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
por: Dolai, Subhankar, et al.
Publicado: (2016)

Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
por: Tamayo, Alejandro, et al.
Publicado: (2022)

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
por: Kruit, Janine K., et al.
Publicado: (2011)

Novel Stable Isotope Analyses Demonstrate Significant Rates of Glucose Cycling in Mouse Pancreatic Islets
por: Wall, Martha L., et al.
Publicado: (2015)

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
por: Kato, Toyonori, et al.
Publicado: (2008)

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
por: Tian, Geng, et al.
Publicado: (2011)

Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion
por: Trevino, Michelle B., et al.
Publicado: (2015)

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion
por: Georgiadou, Eleni, et al.
Publicado: (2022)

miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets
por: Wijesekara, Nadeeja, et al.
Publicado: (2012)

Islet inflammation is associated with pancreatic fatty infiltration and hyperglycemia in type 2 diabetes
por: Horii, Tomomi, et al.
Publicado: (2020)

Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance
por: Wong, Winifred P.S., et al.
Publicado: (2008)

Intracutaneous Transplantation of Islets Within a Biodegradable Temporizing Matrix as an Alternative Site for Islet Transplantation
por: Rojas-Canales, Darling, et al.
Publicado: (2023)

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
por: Sloop, Kyle W., et al.
Publicado: (2010)

Increased β-Cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice
por: Declercq, Jeroen, et al.
Publicado: (2010)

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
por: Hauge-Evans, Astrid C., et al.
Publicado: (2009)

Inhibition of Glucose-Stimulated Insulin Secretion by KCNJ15, a Newly Identified Susceptibility Gene for Type 2 Diabetes
por: Okamoto, Koji, et al.
Publicado: (2012)

Glucose and Pharmacological Modulators of ATP-Sensitive K(+) Channels Control [Ca(2+)](c) by Different Mechanisms in Isolated Mouse α-Cells
por: Quoix, Nicolas, et al.
Publicado: (2009)

Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization
por: Johansson, Ulrika, et al.
Publicado: (2008)

Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats
por: Jaeckle Santos, Lane J., et al.
Publicado: (2014)

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
por: Kaihara, Kelly A., et al.
Publicado: (2015)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion
por: Leloup, Corinne, et al.
Publicado: (2009)

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion
por: Cohen, Guy, et al.
Publicado: (2011)

Ca(2+), Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases
por: Sompol, Pradoldej, et al.
Publicado: (2018)

Islet-1 Is Essential for Pancreatic β-Cell Function
por: Ediger, Benjamin N., et al.
Publicado: (2014)

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
por: Marzban, Lucy, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_bjmbek5ag4m2oc3ob825o1mjso