Discovery of 2-(4-Methylfuran-2(5H)-ylidene)malononitrile and Thieno[3,2-b]thiophene-2-carboxylic Acid Derivatives as G Protein-Coupled Receptor 35 (GPR35) Agonists

[Image: see text] Screening with dynamic mass redistribution (DMR) assays in a native cell line HT-29 led to identification of two novel series of chemical compounds, 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives, as GPR35 agonists. Of these, 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Huayun, Hu, Haibei, He, Mingqian, Hu, Jieyu, Niu, Weijun, Ferrie, Ann M., Fang, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198121/
https://www.ncbi.nlm.nih.gov/pubmed/21950657
http://dx.doi.org/10.1021/jm200999f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198121/
https://www.ncbi.nlm.nih.gov/pubmed/21950657
http://dx.doi.org/10.1021/jm200999f

Ejemplares similares