Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design

Background TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated for slow enrollment before regulatory approval of use of phase II patients in phase III. Purpose (1) To review the trial design and comprehensive type I error...

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Detalles Bibliográficos
Autores principales: Levin, Bruce, Thompson, John LP, Chakraborty, Bibhas, Levy, Gilberto, MacArthur, Robert, Haley, E Clarke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2011
Materias:
Design
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198122/
https://www.ncbi.nlm.nih.gov/pubmed/21737464
http://dx.doi.org/10.1177/1740774511410582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198122/
https://www.ncbi.nlm.nih.gov/pubmed/21737464
http://dx.doi.org/10.1177/1740774511410582

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