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Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design

Background TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated for slow enrollment before regulatory approval of use of phase II patients in phase III. Purpose (1) To review the trial design and comprehensive type I error...

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Detalles Bibliográficos
Autores principales:	Levin, Bruce, Thompson, John LP, Chakraborty, Bibhas, Levy, Gilberto, MacArthur, Robert, Haley, E Clarke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2011
Materias:	Design
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198122/ https://www.ncbi.nlm.nih.gov/pubmed/21737464 http://dx.doi.org/10.1177/1740774511410582

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