Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim(−/−) mice

Dysregulation of either the extrinsic or intrinsic apoptotic pathway can lead to various diseases including immune disorders and cancer. In addition to its role in the extrinsic apoptotic pathway, caspase-8 plays nonapoptotic functions and is essential for T cell homeostasis. The pro-apoptotic BH3-o...

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Detalles Bibliográficos
Autores principales: Bohgaki, Toshiyuki, Mozo, Julien, Salmena, Leonardo, Matysiak-Zablocki, Elzbieta, Bohgaki, Miyuki, Sanchez, Otto, Strasser, Andreas, Hakem, Anne, Hakem, Razqallah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198166/
https://www.ncbi.nlm.nih.gov/pubmed/22006951
http://dx.doi.org/10.1083/jcb.201103053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198166/
https://www.ncbi.nlm.nih.gov/pubmed/22006951
http://dx.doi.org/10.1083/jcb.201103053

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