The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

Centriole duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis. Plk4 (Polo-like kinase 4) activity initiates centriole duplication and is regulated by ubiquitin-mediated proteolysis. Throughou...

Descripción completa

Detalles Bibliográficos
Autores principales: Brownlee, Christopher W., Klebba, Joey E., Buster, Daniel W., Rogers, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198173/
https://www.ncbi.nlm.nih.gov/pubmed/21987638
http://dx.doi.org/10.1083/jcb.201107086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198173/
https://www.ncbi.nlm.nih.gov/pubmed/21987638
http://dx.doi.org/10.1083/jcb.201107086

Ejemplares similares