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The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

Centriole duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis. Plk4 (Polo-like kinase 4) activity initiates centriole duplication and is regulated by ubiquitin-mediated proteolysis. Throughou...

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Detalles Bibliográficos
Autores principales:	Brownlee, Christopher W., Klebba, Joey E., Buster, Daniel W., Rogers, Gregory C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198173/ https://www.ncbi.nlm.nih.gov/pubmed/21987638 http://dx.doi.org/10.1083/jcb.201107086

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