A Multi-Compartment, Single and Multiple Dose Pharmacokinetic Study of the Vaginal Candidate Microbicide 1% Tenofovir Gel

BACKGROUND: Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical. METHODS AND FINDINGS: Forty-nine participants entered a two-phase study: single-dose (SD) and mult...

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Detalles Bibliográficos
Autores principales: Schwartz, Jill L., Rountree, Wes, Kashuba, Angela D. M., Brache, Vivian, Creinin, Mitchell D., Poindexter, Alfred, Kearney, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198383/
https://www.ncbi.nlm.nih.gov/pubmed/22039430
http://dx.doi.org/10.1371/journal.pone.0025974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198383/
https://www.ncbi.nlm.nih.gov/pubmed/22039430
http://dx.doi.org/10.1371/journal.pone.0025974

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