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Mechanism of Disruption of the Amt-GlnK Complex by P(II)-Mediated Sensing of 2-Oxoglutarate

GlnK proteins regulate the active uptake of ammonium by Amt transport proteins by inserting their regulatory T-loops into the transport channels of the Amt trimer and physically blocking substrate passage. They sense the cellular nitrogen status through 2-oxoglutarate, and the energy level of the ce...

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Detalles Bibliográficos
Autores principales: Maier, Sarah, Schleberger, Paula, Lü, Wei, Wacker, Tobias, Pflüger, Tobias, Litz, Claudia, Andrade, Susana L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198391/
https://www.ncbi.nlm.nih.gov/pubmed/22039461
http://dx.doi.org/10.1371/journal.pone.0026327