Cargando…
Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs
Since the discovery of RNAi and microRNAs more than 10 years ago, much research has focused on the development of systems that usurp microRNA pathways to downregulate gene expression in mammalian cells. One of these systems makes use of endogenous microRNA pri-cursors that are expressed from polymer...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198731/ https://www.ncbi.nlm.nih.gov/pubmed/22031824 http://dx.doi.org/10.1371/journal.pone.0026213 |