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Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs

Since the discovery of RNAi and microRNAs more than 10 years ago, much research has focused on the development of systems that usurp microRNA pathways to downregulate gene expression in mammalian cells. One of these systems makes use of endogenous microRNA pri-cursors that are expressed from polymer...

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Detalles Bibliográficos
Autores principales:	Lebbink, Robert Jan, Lowe, Maggie, Chan, Theresa, Khine, Htet, Wang, Xiaoyin, McManus, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198731/ https://www.ncbi.nlm.nih.gov/pubmed/22031824 http://dx.doi.org/10.1371/journal.pone.0026213

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