The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids

BACKGROUND: Cannabinoid 2 receptor (CB2R) agonists attenuate inflammatory pain but the precise mechanism implicated in these effects is not completely elucidated. We investigated if the peripheral nitric oxide-cGMP-protein kinase G (PKG)-ATP-sensitive K(+) (KATP) channels signaling pathway triggered...

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Detalles Bibliográficos
Autores principales: Negrete, Roger, Hervera, Arnau, Leánez, Sergi, Martín-Campos, Jesús M., Pol, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198780/
https://www.ncbi.nlm.nih.gov/pubmed/22031841
http://dx.doi.org/10.1371/journal.pone.0026688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198780/
https://www.ncbi.nlm.nih.gov/pubmed/22031841
http://dx.doi.org/10.1371/journal.pone.0026688

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