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Targeted Deletion of Nrf2 Reduces Urethane-Induced Lung Tumor Development in Mice

Nrf2 is a key transcription factor that regulates cellular redox and defense responses. However, permanent Nrf2 activation in human lung carcinomas promotes pulmonary malignancy and chemoresistance. We tested the hypothesis that Nrf2 has cell survival properties and lack of Nrf2 suppresses chemicall...

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Detalles Bibliográficos
Autores principales: Bauer, Alison K., Cho, Hye-Youn, Miller-DeGraff, Laura, Walker, Christopher, Helms, Katherine, Fostel, Jennifer, Yamamoto, Masayuki, Kleeberger, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198791/
https://www.ncbi.nlm.nih.gov/pubmed/22039513
http://dx.doi.org/10.1371/journal.pone.0026590