Cargando…

DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression

DNA damage commonly occurs in cancer cells as a result of endogenous and tumor microenvironmental stress. In this study, we applied immunohistochemistry to study the expression of phosphorylated Chk2 (pChk2), a surrogate marker of the DNA damage response, in high grade and low grade of ovarian serou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kshirsagar, Malti, Jiang, Wei, Shih, Ie-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199114/ https://www.ncbi.nlm.nih.gov/pubmed/22028712 http://dx.doi.org/10.1155/2012/621685

Ejemplares similares

Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase
por: Sehdev, Ann Smith, et al.
Publicado: (2010)

Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics
por: Gross, Amy L., et al.
Publicado: (2010)

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma
por: Ducie, Jennifer, et al.
Publicado: (2017)

A survival analysis comparing women with ovarian low-grade serous carcinoma to those with high-grade histology
por: Chen, Ming, et al.
Publicado: (2014)

Multiomic characterization of high-grade serous ovarian carcinoma: editorial commentary on recent application and consideration for future directions
por: Jones, Tiffany Nicole, et al.
Publicado: (2023)

Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage
por: Min, Sunwoo, et al.
Publicado: (2018)

RSF-1 overexpression determines cancer progression and drug resistance in cervical cancer
por: Wang, Xiangyu, et al.
Publicado: (2018)

Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma
por: Jiang, Rosie T., et al.
Publicado: (2017)

Amplification of The ch19p13.2 NACC1 Locus in Ovarian High-grade Serous Carcinoma
por: Shih, Ie-Ming, et al.
Publicado: (2011)

High grade serous ovarian carcinomas originate in the fallopian tube
por: Labidi-Galy, S. Intidhar, et al.
Publicado: (2017)

RNA‐Peptide nanoplexes drug DNA damage pathways in high‐grade serous ovarian tumors
por: Dreaden, Erik C., et al.
Publicado: (2018)

RSF1 in cancer: interactions and functions
por: Cai, Guiyang, et al.
Publicado: (2021)

Low-grade Serous Ovarian Carcinoma
por: Ricciardi, Enzo, et al.
Publicado: (2018)

Low-Grade Ovarian Serous Adenocarcinoma with Lymph Node Metastasis in Neck
por: Chen, Shih-Lung, et al.
Publicado: (2021)

Low-grade serous ovarian cancer: expert consensus report on the state of the science
por: Grisham, Rachel N, et al.
Publicado: (2023)

Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer
por: Silva, Vera L., et al.
Publicado: (2021)

Primary and recurrent ovarian high-grade serous carcinomas display similar microRNA expression patterns relative to those of normal ovarian tissue
por: Nam, Eun Ji, et al.
Publicado: (2016)

CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma
por: Kuhn, Elisabetta, et al.
Publicado: (2016)

Testing for NRAS Mutations in Serous Borderline Ovarian Tumors and Low-Grade Serous Ovarian Carcinomas
por: Sadlecki, Pawel, et al.
Publicado: (2018)

Development of Low-Grade Serous Ovarian Carcinoma from Benign Ovarian Serous Cystadenoma Cells
por: Dey, Puja, et al.
Publicado: (2022)

Ovarian cancer cell lines derived from non-serous carcinomas migrate and invade more aggressively than those derived from high-grade serous carcinomas
por: Hallas-Potts, Amelia, et al.
Publicado: (2019)

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
por: Sanij, Elaine, et al.
Publicado: (2020)

Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
por: Kanakkanthara, Arun, et al.
Publicado: (2022)

Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple-negative breast and serous ovarian cancers
por: Birkbak, N J, et al.
Publicado: (2018)

Intratumoral expression analysis reveals that OX40 and TIM-3 are prominently expressed and have variable associations with clinical outcomes in high grade serous ovarian cancer
por: James, Nicole E., et al.
Publicado: (2022)

BRAF(V600E)-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma
por: Chui, M. Herman, et al.
Publicado: (2019)

The Scarface Score: Deciphering Response to DNA Damage Agents in High-Grade Serous Ovarian Cancer—A GEICO Study
por: Fernández-Serra, Antonio, et al.
Publicado: (2023)

Targeting the Microenvironment in High Grade Serous Ovarian Cancer
por: Nwani, Nkechiyere G., et al.
Publicado: (2018)

The Tumor Microenvironment of High Grade Serous Ovarian Cancer
por: Stack, M. Sharon, et al.
Publicado: (2018)

Cell Origins of High-Grade Serous Ovarian Cancer
por: Kim, Jaeyeon, et al.
Publicado: (2018)

Proteome profiling of low grade serous ovarian cancer
por: zadeh fakhar, Haniyeh Bashi, et al.
Publicado: (2019)

High-grade serous ovarian cancer: the clone wars
por: Salomon-Perzyński, Aleksander, et al.
Publicado: (2017)

Molecular Management of High-Grade Serous Ovarian Carcinoma
por: Punzón-Jiménez, Paula, et al.
Publicado: (2022)

Correction: BRAF(V600E)-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma
por: Chui, M. Herman, et al.
Publicado: (2021)

Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas
por: Milanesio, Michela Camilla, et al.
Publicado: (2020)

Low-grade serous carcinoma with extensive osseous metaplasia arising from ovarian serous cystadenofibroma
por: Ribeiro e Ribeiro, Renan, et al.
Publicado: (2021)

Active establishment of centromeric CENP-A chromatin by RSF complex
por: Perpelescu, Marinela, et al.
Publicado: (2009)

Effects of RSF-1 on proliferation and apoptosis of breast cancer cells
por: Liu, Yuhui, et al.
Publicado: (2018)

The peritoneal tumour microenvironment of high-grade serous ovarian cancer
por: Leinster, D Andrew, et al.
Publicado: (2012)

Trends of low-grade serous ovarian carcinoma in the United States
por: Matsuo, Koji, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_up2afsnte56mhr7q7go934c1oo