A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane

Recently, an inverse relationship between resistance to platinum-based chemotherapeutic agents and taxanes has been implicated in breast and ovarian cancers, and a possible pivotal role for BRCA1 has also been suggested. Because cis-diamminedichloroplatinum (CDDP) and taxanes are the most active ant...

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Detalles Bibliográficos
Autores principales: Saiki, Yuriko, Ogawa, Takenori, Shiga, Kiyoto, Sunamura, Makoto, Kobayashi, Toshimitsu, Horii, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199181/
https://www.ncbi.nlm.nih.gov/pubmed/22046189
http://dx.doi.org/10.1155/2011/521852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199181/
https://www.ncbi.nlm.nih.gov/pubmed/22046189
http://dx.doi.org/10.1155/2011/521852

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