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An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer

Dicer proteins function in RNA interference (RNAi) pathways by generating small RNAs (sRNAs). Here, we report the solution structure of the C-terminal domain of Schizosaccharomyces pombe Dicer (Dcr1). The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel...

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Detalles Bibliográficos
Autores principales:	Barraud, Pierre, Emmerth, Stephan, Shimada, Yukiko, Hotz, Hans-Rudolf, Allain, Frédéric H-T, Bühler, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199388/ https://www.ncbi.nlm.nih.gov/pubmed/21847092 http://dx.doi.org/10.1038/emboj.2011.300

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