Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

ADAR2 catalyses the deamination of adenosine to inosine at the GluR2 Q/R site in the pre-mRNA encoding the critical subunit of AMPA receptors. Among ADAR2 substrates this is the vital one as editing at this position is indispensable for normal brain function. However, the regulation of ADAR2 post-tr...

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Detalles Bibliográficos
Autores principales: Marcucci, Roberto, Brindle, James, Paro, Simona, Casadio, Angela, Hempel, Sophie, Morrice, Nicholas, Bisso, Andrea, Keegan, Liam P, Del Sal, Giannino, O'Connell, Mary A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199391/
https://www.ncbi.nlm.nih.gov/pubmed/21847096
http://dx.doi.org/10.1038/emboj.2011.303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199391/
https://www.ncbi.nlm.nih.gov/pubmed/21847096
http://dx.doi.org/10.1038/emboj.2011.303

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