Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation

Chemotherapy resistance poses severe limitations on the efficacy of anti-cancer medications. Recently, the notion of using novel combinations of ‘old' drugs for new indications has garnered significant interest. The potential of using phenothiazines as chemosensitizers has been suggested earlie...

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Detalles Bibliográficos
Autores principales: Zong, D, Hååg, P, Yakymovych, I, Lewensohn, R, Viktorsson, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199719/
https://www.ncbi.nlm.nih.gov/pubmed/21776019
http://dx.doi.org/10.1038/cddis.2011.62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199719/
https://www.ncbi.nlm.nih.gov/pubmed/21776019
http://dx.doi.org/10.1038/cddis.2011.62

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