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Regulation of TGF-β1-Induced Pro-Apoptotic Signaling by Growth Factor Receptors and Extracellular Matrix Receptor Integrins in the Liver

Hepatocellular carcinoma (HCC) often arises from chronically diseased livers. Persistent liver inflammation causes the accumulation of excessive extracellular matrix (ECM) proteins and impairs the liver function, finally leading to the development of HCC. A pleiotropic cytokine, transforming growth...

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Detalles Bibliográficos
Autores principales: Ozaki, Iwata, Hamajima, Hiroshi, Matsuhashi, Sachiko, Mizuta, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199809/
https://www.ncbi.nlm.nih.gov/pubmed/22028694
http://dx.doi.org/10.3389/fphys.2011.00078