Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

BACKGROUND: Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis. However, side effects of first generation inhibitors included altered levels of related cathepsins in perip...

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Detalles Bibliográficos
Autores principales: Dauth, Stephanie, Sîrbulescu, Ruxandra F, Jordans, Silvia, Rehders, Maren, Avena, Linda, Oswald, Julia, Lerchl, Alexander, Saftig, Paul, Brix, Klaudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199875/
https://www.ncbi.nlm.nih.gov/pubmed/21794126
http://dx.doi.org/10.1186/1471-2202-12-74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199875/
https://www.ncbi.nlm.nih.gov/pubmed/21794126
http://dx.doi.org/10.1186/1471-2202-12-74

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