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The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis

Several clinical studies have demonstrated that the humanized anti-interleukin-6 (IL-6) receptor antibody tocilizumab (TCZ) improves clinical symptoms and prevents progression of joint destruction in rheumatoid arthritis (RA). However, the precise mechanism by which IL-6 blockade leads to the improv...

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Detalles Bibliográficos
Autores principales: Hashizume, Misato, Mihara, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199948/
https://www.ncbi.nlm.nih.gov/pubmed/22046525
http://dx.doi.org/10.1155/2011/765624