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Evidence of MexT-Independent Overexpression of MexEF-OprN Multidrug Efflux Pump of Pseudomonas aeruginosa in Presence of Metabolic Stress

BACKGROUND: The Pseudomonas aeruginosa MexEF-OprN efflux pump confers resistance to clinically significant antibiotics. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. METHODOLOGY: We have exploited the impaired...

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Detalles Bibliográficos
Autores principales: Kumar, Ayush, Schweizer, Herbert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200333/
https://www.ncbi.nlm.nih.gov/pubmed/22039504
http://dx.doi.org/10.1371/journal.pone.0026520