Cargando…

Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation

BACKGROUND: The yeast Saccharomyces cerevisiae responds to amino acid starvation by inducing the transcription factor Gcn4. This is mainly mediated via a translational control mechanism dependent upon the translation initiation eIF2·GTP·Met-tRNA(i)(Met )ternary complex, and the four short upstream o...

Descripción completa

Detalles Bibliográficos
Autores principales:	You, Tao, Stansfield, Ian, Romano, M Carmen, Brown, Alistair JP, Coghill, George M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201031/ https://www.ncbi.nlm.nih.gov/pubmed/21851603 http://dx.doi.org/10.1186/1752-0509-5-131

Ejemplares similares

A quantitative model for the GCN4 translational control in Saccharomyces cerevisiae
por: You, Tao, et al.
Publicado: (2007)

GCN sensitive protein translation in yeast
por: Barr, William A., et al.
Publicado: (2020)

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast
por: Magazinnik, Tanya, et al.
Publicado: (2005)

Definition of the Minimal Contents for the Molecular Simulation of the Yeast Cytoplasm
por: Kompella, Vijay Phanindra Srikanth, et al.
Publicado: (2019)

Efficient simulation of stochastic chemical kinetics with the Stochastic Bulirsch-Stoer extrapolation method
por: Székely, Tamás, et al.
Publicado: (2014)

A yeast tRNA mutant that causes pseudohyphal growth exhibits reduced rates of CAG codon translation
por: Kemp, Alain J, et al.
Publicado: (2013)

Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation
por: Gorgoni, Barbara, et al.
Publicado: (2016)

CERENA: ChEmical REaction Network Analyzer—A Toolbox for the Simulation and Analysis of Stochastic Chemical Kinetics
por: Kazeroonian, Atefeh, et al.
Publicado: (2016)

Chemical kinetics, stochastic processes, and irreversible thermodynamics
por: Santillán, Moisés
Publicado: (2014)

Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway
por: Romero, Antonia María, et al.
Publicado: (2020)

Ribosome Traffic on mRNAs Maps to Gene Ontology: Genome-wide Quantification of Translation Initiation Rates and Polysome Size Regulation
por: Ciandrini, Luca, et al.
Publicado: (2013)

The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels
por: McFarland, Matthew R, et al.
Publicado: (2020)

Stochastic scanning events on the GCN4 mRNA 5’ untranslated region generate cell-to-cell heterogeneity in the yeast nutritional stress response
por: Meng, Xiang, et al.
Publicado: (2023)

Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
por: Hu, Zheng, et al.
Publicado: (2018)

Approximate maximum likelihood estimation for stochastic chemical kinetics
por: Andreychenko, Aleksandr, et al.
Publicado: (2012)

Multiomics of GCN4-Dependent Replicative Lifespan Extension Models Reveals Gcn4 as a Regulator of Protein Turnover in Yeast
por: Mariner, Blaise L., et al.
Publicado: (2023)

Stochastic simulations of a synthetic bacteria-yeast ecosystem
por: Biliouris, Konstantinos, et al.
Publicado: (2012)

A stochastic model for simulating ribosome kinetics in vivo
por: Dykeman, Eric Charles
Publicado: (2020)

Gcn4 impacts metabolic fluxes to promote yeast chronological lifespan
por: Gulias, Juan Facundo, et al.
Publicado: (2023)

Beyond the chemical master equation: Stochastic chemical kinetics coupled with auxiliary processes
por: Lunz, Davin, et al.
Publicado: (2021)

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation
por: Ishimura, Ryuta, et al.
Publicado: (2016)

Qualitative, semi-quantitative, and quantitative simulation of the osmoregulation system in yeast
por: Pang, Wei, et al.
Publicado: (2015)

Maximum Probability Reaction Sequences in Stochastic Chemical Kinetic Systems
por: Salehi, Maryam, et al.
Publicado: (2010)

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile
por: Bonnin, Pierre, et al.
Publicado: (2017)

A dynamical stochastic model of yeast translation across the cell cycle
por: Seeger, Martin, et al.
Publicado: (2023)

Stochastic simulation for the inference of transcriptional control network of yeast cyclins genes
por: Vohradsky, Jiri
Publicado: (2012)

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
por: Mittal, Nitish, et al.
Publicado: (2017)

Comparison of Models for IP(3) Receptor Kinetics Using Stochastic Simulations
por: Hituri, Katri, et al.
Publicado: (2013)

Stochastic simulation and statistical inference platform for visualization and estimation of transcriptional kinetics
por: Gorin, Gennady, et al.
Publicado: (2020)

PPA-GCN: A Efficient GCN Framework for Prokaryotic Pathways Assignment
por: Lu, Yuntao, et al.
Publicado: (2022)

Phylogenetic diversity of stress signalling pathways in fungi
por: Nikolaou, Elissavet, et al.
Publicado: (2009)

Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion
por: Fröhlich, Fabian, et al.
Publicado: (2016)

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast
por: Islam, Azharul, et al.
Publicado: (2011)

A Plant Virus Movement Protein Regulates the Gcn2p Kinase in Budding Yeast
por: Aparicio, Frederic, et al.
Publicado: (2011)

Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines
por: Huang, Boyue, et al.
Publicado: (2020)

kGCN: a graph-based deep learning framework for chemical structures
por: Kojima, Ryosuke, et al.
Publicado: (2020)

pSSAlib: The partial-propensity stochastic chemical network simulator
por: Ostrenko, Oleksandr, et al.
Publicado: (2017)

GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2α in Arabidopsis
por: Zhang, Yuhua, et al.
Publicado: (2008)

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
por: Müller, Martin B.D., et al.
Publicado: (2023)

Correction: Comparison of Models for IP(3) Receptor Kinetics Using Stochastic Simulations
por: Hituri, Katri, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4cu71rht2k8rkempb8ape5tkji