Stability and Mismatch Discrimination of Locked Nucleic Acid–DNA Duplexes

[Image: see text] Locked nucleic acids (LNA; symbols of bases, +A, +C, +G, and +T) are introduced into chemically synthesized oligonucleotides to increase duplex stability and specificity. To understand these effects, we have determined thermodynamic parameters of consecutive LNA nucleotides. We pre...

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Detalles Bibliográficos
Autores principales: Owczarzy, Richard, You, Yong, Groth, Christopher L., Tataurov, Andrey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201676/
https://www.ncbi.nlm.nih.gov/pubmed/21928795
http://dx.doi.org/10.1021/bi200904e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201676/
https://www.ncbi.nlm.nih.gov/pubmed/21928795
http://dx.doi.org/10.1021/bi200904e

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