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Stability and Mismatch Discrimination of Locked Nucleic Acid–DNA Duplexes
[Image: see text] Locked nucleic acids (LNA; symbols of bases, +A, +C, +G, and +T) are introduced into chemically synthesized oligonucleotides to increase duplex stability and specificity. To understand these effects, we have determined thermodynamic parameters of consecutive LNA nucleotides. We pre...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201676/ https://www.ncbi.nlm.nih.gov/pubmed/21928795 http://dx.doi.org/10.1021/bi200904e |