Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

All organisms, including humans, possess a huge number of uncharacterized enzymes. Here, we describe a general cell-based screen for enzyme substrate discovery by untargeted metabolomics and its application to identify α/β-hydrolase domain-containing 3 (ABHD3) as a lipase that selectively cleaves me...

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Detalles Bibliográficos
Autores principales: Long, Jonathan Z., Cisar, Justin S., Milliken, David, Niessen, Sherry, Wang, Chu, Trauger, Sunia A., Siuzdak, Gary, Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201731/
https://www.ncbi.nlm.nih.gov/pubmed/21926997
http://dx.doi.org/10.1038/nchembio.659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201731/
https://www.ncbi.nlm.nih.gov/pubmed/21926997
http://dx.doi.org/10.1038/nchembio.659

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