Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome

Hepatitis B virus (HBV) pregenomic RNA contains a hairpin structure (ϵ) located in the preCore region, essential for viral replication. ϵ stability is enhanced by the presence of preCore variants and ϵ is recognized by the HBV polymerase (Pol). Mutations in the retrotranscriptase domain (YMDD) of Po...

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Detalles Bibliográficos
Autores principales: Homs, Maria, Buti, Maria, Quer, Josep, Jardí, Rosendo, Schaper, Melanie, Tabernero, David, Ortega, Israel, Sanchez, Alex, Esteban, Rafael, Rodriguez-Frias, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201856/
https://www.ncbi.nlm.nih.gov/pubmed/21742757
http://dx.doi.org/10.1093/nar/gkr451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201856/
https://www.ncbi.nlm.nih.gov/pubmed/21742757
http://dx.doi.org/10.1093/nar/gkr451

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