Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair

In cells exposed to ionizing radiation (IR), double-strand breaks (DSBs) form within clustered-damage sites from lesions disrupting the DNA sugar–phosphate backbone. It is commonly assumed that these DSBs form promptly and are immediately detected and processed by the cellular DNA damage response (D...

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Detalles Bibliográficos
Autores principales: Singh, Satyendra K., Wang, Minli, Staudt, Christian, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201859/
https://www.ncbi.nlm.nih.gov/pubmed/21745815
http://dx.doi.org/10.1093/nar/gkr463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201859/
https://www.ncbi.nlm.nih.gov/pubmed/21745815
http://dx.doi.org/10.1093/nar/gkr463

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