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Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair
In cells exposed to ionizing radiation (IR), double-strand breaks (DSBs) form within clustered-damage sites from lesions disrupting the DNA sugar–phosphate backbone. It is commonly assumed that these DSBs form promptly and are immediately detected and processed by the cellular DNA damage response (D...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201859/ https://www.ncbi.nlm.nih.gov/pubmed/21745815 http://dx.doi.org/10.1093/nar/gkr463 |