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RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency

Obtaining homogeneous population of natively folded RNAs is a crippling problem encountered when preparing RNAs for structural or enzymatic studies. Most of the traditional methods that are employed to prepare large quantities of RNAs involve procedures that partially denature the RNA. Here, we pres...

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Detalles Bibliográficos
Autores principales: Luo, Yiling, Eldho, Nadukkudy V., Sintim, Herman O., Dayie, T. Kwaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201860/
https://www.ncbi.nlm.nih.gov/pubmed/21742763
http://dx.doi.org/10.1093/nar/gkr464