Role of the closing base pair for d(GCA) hairpin stability: free energy analysis and folding simulations

Hairpin loops belong to the most important structural motifs in folded nucleic acids. The d(GNA) sequence in DNA can form very stable trinucleotide hairpin loops depending, however, strongly on the closing base pair. Replica-exchange molecular dynamics (REMD) were employed to study hairpin folding o...

Descripción completa

Detalles Bibliográficos
Autores principales: Kannan, Srinivasaraghavan, Zacharias, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201870/
https://www.ncbi.nlm.nih.gov/pubmed/21724608
http://dx.doi.org/10.1093/nar/gkr541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201870/
https://www.ncbi.nlm.nih.gov/pubmed/21724608
http://dx.doi.org/10.1093/nar/gkr541

Ejemplares similares