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Role of the closing base pair for d(GCA) hairpin stability: free energy analysis and folding simulations
Hairpin loops belong to the most important structural motifs in folded nucleic acids. The d(GNA) sequence in DNA can form very stable trinucleotide hairpin loops depending, however, strongly on the closing base pair. Replica-exchange molecular dynamics (REMD) were employed to study hairpin folding o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201870/ https://www.ncbi.nlm.nih.gov/pubmed/21724608 http://dx.doi.org/10.1093/nar/gkr541 |