UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Cytotoxicity of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FdUrd) due to DNA fragmentation during DNA repair has been proposed as an alternative to effects from thymidylate synthase (TS) inhibition or RNA incorporation. The goal of the present study was to investigate the relative contributio...

Descripción completa

Detalles Bibliográficos
Autores principales: Pettersen, Henrik Sahlin, Visnes, Torkild, Vågbø, Cathrine Broberg, Svaasand, Eva. K., Doseth, Berit, Slupphaug, Geir, Kavli, Bodil, Krokan, Hans E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201877/
https://www.ncbi.nlm.nih.gov/pubmed/21745813
http://dx.doi.org/10.1093/nar/gkr563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201877/
https://www.ncbi.nlm.nih.gov/pubmed/21745813
http://dx.doi.org/10.1093/nar/gkr563

Ejemplares similares