SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data

We develop a statistical tool SNVer for calling common and rare variants in analysis of pooled or individual next-generation sequencing (NGS) data. We formulate variant calling as a hypothesis testing problem and employ a binomial–binomial model to test the significance of observed allele frequency...

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Detalles Bibliográficos
Autores principales: Wei, Zhi, Wang, Wei, Hu, Pingzhao, Lyon, Gholson J., Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201884/
https://www.ncbi.nlm.nih.gov/pubmed/21813454
http://dx.doi.org/10.1093/nar/gkr599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201884/
https://www.ncbi.nlm.nih.gov/pubmed/21813454
http://dx.doi.org/10.1093/nar/gkr599

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