A Malaria Vaccine Based on the Polymorphic Block 2 Region of MSP-1 that Elicits a Broad Serotype-Spanning Immune Response

Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A synthetic MSP-1 Block 2 construct, based on all polymorphic variants found in natural Plasmodium falciparum isolates has been designed, combined...

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Detalles Bibliográficos
Autores principales: Cowan, Graeme J. M., Creasey, Alison M., Dhanasarnsombut, Kelwalin, Thomas, Alan W., Remarque, Edmond J., Cavanagh, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202563/
https://www.ncbi.nlm.nih.gov/pubmed/22073118
http://dx.doi.org/10.1371/journal.pone.0026616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202563/
https://www.ncbi.nlm.nih.gov/pubmed/22073118
http://dx.doi.org/10.1371/journal.pone.0026616

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