Cargando…

A Malaria Vaccine Based on the Polymorphic Block 2 Region of MSP-1 that Elicits a Broad Serotype-Spanning Immune Response

Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A synthetic MSP-1 Block 2 construct, based on all polymorphic variants found in natural Plasmodium falciparum isolates has been designed, combined...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cowan, Graeme J. M., Creasey, Alison M., Dhanasarnsombut, Kelwalin, Thomas, Alan W., Remarque, Edmond J., Cavanagh, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202563/ https://www.ncbi.nlm.nih.gov/pubmed/22073118 http://dx.doi.org/10.1371/journal.pone.0026616

Ejemplares similares

Merozoite surface protein 3.3C-specific antibodies block the intraerythrocytic development of Plasmodium falciparum and induce parasite apoptosis
por: Harris, Lvnne M, et al.
Publicado: (2012)

Cohort study of the association of antibody levels to AMA1, MSP1(19), MSP3 and GLURP with protection from clinical malaria in Ghanaian children
por: Dodoo, Daniel, et al.
Publicado: (2008)

A Novel Malaria Vaccine Candidate Antigen Expressed in Tetrahymena thermophila
por: Cowan, Graeme J. M., et al.
Publicado: (2014)

Genetic Diversity of Polymorphic Marker Merozoite Surface Protein 1 (Msp-1) and 2 (Msp-2) Genes of Plasmodium falciparum Isolates From Malaria Endemic Region of Pakistan
por: Khan, Shahid Niaz, et al.
Publicado: (2021)

Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations
por: Oboh, Mary A., et al.
Publicado: (2021)

Humoral and cell-mediated immunity to MSP3 peptides in adults immunized with MSP3 in malaria endemic area, Burkina Faso
por: NEBIE, I, et al.
Publicado: (2009)

Plasmodium falciparum Genetic Diversity in Panamá Based on glurp, msp-1 and msp-2 Genes: Implications for Malaria Elimination in Mesoamerica
por: Santamaría, Ana María, et al.
Publicado: (2020)

Multifunctional IgG/IgM antibodies and cellular cytotoxicity are elicited by the full-length MSP1 SumayaVac-1 malaria vaccine
por: Rosenkranz, Micha, et al.
Publicado: (2023)

Genetic Polymorphism of msp1 and msp2 in Plasmodium falciparum Isolates from Côte d'Ivoire versus Gabon
por: Yavo, William, et al.
Publicado: (2016)

MSP For Dummies
por: Ferguson, Alan
Publicado: (2014)

Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting
por: Noranate, Nitchakarn, et al.
Publicado: (2009)

Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas
por: Adu, Bright, et al.
Publicado: (2016)

Five Complete Genome Sequences Spanning the Dutch Streptococcus suis Serotype 2 and Serotype 9 Populations
por: van der Putten, Boas C. L., et al.
Publicado: (2020)

Allelic diversity of merozoite surface protein genes (msp1 and msp2) and clinical manifestations of Plasmodium falciparum malaria cases in Aceh, Indonesia
por: Jamil, Kurnia Fitri, et al.
Publicado: (2021)

The N-Terminal Region of Plasmodium falciparum MSP10 Is a Target of Protective Antibodies in Malaria and Is Important for PfGAMA/PfMSP10 Interaction
por: Nagaoka, Hikaru, et al.
Publicado: (2019)

Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent
por: Verma, Anju, et al.
Publicado: (2016)

Pre-Clinical Assessment of Novel Multivalent MSP3 Malaria Vaccine Constructs
por: Bang, Gilles, et al.
Publicado: (2011)

Improving Methods for Analyzing Antimalarial Drug Efficacy Trials: Molecular Correction Based on Length-Polymorphic Markers msp-1, msp-2, and glurp
por: Jones, S., et al.
Publicado: (2019)

Humoral Immune Response to Mixed PfAMA1 Alleles; Multivalent PfAMA1 Vaccines Induce Broad Specificity
por: Kusi, Kwadwo A., et al.
Publicado: (2009)

Plasmodium falciparum msp1 and msp2 genetic diversity and allele frequencies in parasites isolated from symptomatic malaria patients in Bobo-Dioulasso, Burkina Faso
por: Somé, Anyirékun Fabrice, et al.
Publicado: (2018)

Genetic diversity of Plasmodium falciparum isolates from patients with uncomplicated and severe malaria based on msp-1 and msp-2 genes in Gublak, North West Ethiopia
por: Mohammed, Hussein, et al.
Publicado: (2019)

Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population
por: Kusi, Kwadwo A, et al.
Publicado: (2012)

Marked variation in MSP-1(19 )antibody responses to malaria in western Kenyan highlands
por: Badu, Kingsley, et al.
Publicado: (2012)

Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia
por: Gosi, Panita, et al.
Publicado: (2013)

MSP430 microcontroller basics
por: Davies, J H
Publicado: (2008)

A Phase 1 Trial of MSP2-C1, a Blood-Stage Malaria Vaccine Containing 2 Isoforms of MSP2 Formulated with Montanide® ISA 720
por: McCarthy, James S., et al.
Publicado: (2011)

Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal
por: Ndiaye, Tolla, et al.
Publicado: (2019)

Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT
por: Huang, Bo, et al.
Publicado: (2018)

Genetic Diversity of Plasmodium vivax in Clinical Isolates from Southern Thailand using PvMSP1, PvMSP3 (PvMSP3α, PvMSP3β) Genes and Eight Microsatellite Markers
por: Thanapongpichat, Supinya, et al.
Publicado: (2019)

Designing malaria vaccines to circumvent antigen variability()
por: Ouattara, Amed, et al.
Publicado: (2015)

PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon
por: Villasis, Elizabeth, et al.
Publicado: (2021)

CYP17 MspA1 Polymorphism and Age at Menarche: A Meta-Analysis
por: Pei, Yu-Fang, et al.
Publicado: (2008)

Evolution of Genetic Polymorphisms of Plasmodium falciparum Merozoite Surface Protein (PfMSP) in Thailand
por: Kuesap, Jiraporn, et al.
Publicado: (2014)

Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes
por: Osada, Kensuke
Publicado: (2020)

Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan Africa
por: Mwingira, Felista, et al.
Publicado: (2011)

Genetic diversity of the msp-1, msp-2, and glurp genes of Plasmodium falciparum isolates in Northwest Ethiopia
por: Mohammed, Hussein, et al.
Publicado: (2018)

Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates
por: Ullah, Ibrar, et al.
Publicado: (2022)

Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection
por: Dent, Arlene E, et al.
Publicado: (2012)

Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate
por: Seow, Jeffrey, et al.
Publicado: (2021)

Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum
por: Hellgren, Olof, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tomdgm9hhqeqqvl6rqkubvo6cr