Screening for Active Small Molecules in Mitochondrial Complex I Deficient Patient's Fibroblasts, Reveals AICAR as the Most Beneficial Compound

Congenital deficiency of the mitochondrial respiratory chain complex I (CI) is a common defect of oxidative phosphorylation (OXPHOS). Despite major advances in the biochemical and molecular diagnostics and the deciphering of CI structure, function assembly and pathomechanism, there is currently no s...

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Detalles Bibliográficos
Autores principales: Golubitzky, Anna, Dan, Phyllis, Weissman, Sarah, Link, Gabriela, Wikstrom, Jakob D., Saada, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202581/
https://www.ncbi.nlm.nih.gov/pubmed/22046392
http://dx.doi.org/10.1371/journal.pone.0026883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202581/
https://www.ncbi.nlm.nih.gov/pubmed/22046392
http://dx.doi.org/10.1371/journal.pone.0026883

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