Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

Chronic myelogenous leukemia (CML) is caused by the constitutively active tyrosine kinase Bcr-Abl and treated with the tyrosine kinase inhibitor (TKI) imatinib. However, emerging TKI resistance prevents complete cure. Therefore, alternative strategies targeting regulatory modules of Bcr-Abl in addit...

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Detalles Bibliográficos
Autores principales: Grebien, Florian, Hantschel, Oliver, Wojcik, John, Kaupe, Ines, Kovacic, Boris, Wyrzucki, Arkadiusz M., Gish, Gerald D., Cerny-Reiterer, Sabine, Koide, Akiko, Beug, Hartmut, Pawson, Tony, Valent, Peter, Koide, Shohei, Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202669/
https://www.ncbi.nlm.nih.gov/pubmed/22000011
http://dx.doi.org/10.1016/j.cell.2011.08.046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202669/
https://www.ncbi.nlm.nih.gov/pubmed/22000011
http://dx.doi.org/10.1016/j.cell.2011.08.046

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