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Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action
Several broad-spectrum microbicides, including cellulose sulfate (CS), have passed conventional preclinical and phase I clinical safety evaluation and yet have failed to protect women from acquiring HIV-1 in phase II/III trials. Concerns have been raised that current preclinical algorithms are defic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Microbiology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202752/ https://www.ncbi.nlm.nih.gov/pubmed/22027006 http://dx.doi.org/10.1128/mBio.00168-11 |