Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065

The natural antibiotics CC‑1065 and the duocarmycins are highly cytotoxic compounds which however are not suitable for cancer therapy due to their general toxicity. We have developed glycosidic prodrugs of seco-analogues of these antibiotics for a selective cancer therapy using conjugates of glycohy...

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Detalles Bibliográficos
Autores principales: Tietze, Lutz F., Krewer, Birgit, von Hof, J. Marian, Frauendorf, Holm, Schuberth, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202783/
https://www.ncbi.nlm.nih.gov/pubmed/22069536
http://dx.doi.org/10.3390/toxins1020134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202783/
https://www.ncbi.nlm.nih.gov/pubmed/22069536
http://dx.doi.org/10.3390/toxins1020134

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