Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenes such as K-ras mediate cellular and metabolic transformation during tumorigenesis. To analyze K-Ras-dependent metabolic alterations, we employed (13)C metabolic flux analysis (MFA), non-targeted tracer fate detection (NTFD) of (15)N-labeled glutamine, and transcriptomic profiling in mouse f...

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Detalles Bibliográficos
Autores principales: Gaglio, Daniela, Metallo, Christian M, Gameiro, Paulo A, Hiller, Karsten, Danna, Lara Sala, Balestrieri, Chiara, Alberghina, Lilia, Stephanopoulos, Gregory, Chiaradonna, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202795/
https://www.ncbi.nlm.nih.gov/pubmed/21847114
http://dx.doi.org/10.1038/msb.2011.56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202795/
https://www.ncbi.nlm.nih.gov/pubmed/21847114
http://dx.doi.org/10.1038/msb.2011.56

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