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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenes such as K-ras mediate cellular and metabolic transformation during tumorigenesis. To analyze K-Ras-dependent metabolic alterations, we employed (13)C metabolic flux analysis (MFA), non-targeted tracer fate detection (NTFD) of (15)N-labeled glutamine, and transcriptomic profiling in mouse f...

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Detalles Bibliográficos
Autores principales:	Gaglio, Daniela, Metallo, Christian M, Gameiro, Paulo A, Hiller, Karsten, Danna, Lara Sala, Balestrieri, Chiara, Alberghina, Lilia, Stephanopoulos, Gregory, Chiaradonna, Ferdinando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202795/ https://www.ncbi.nlm.nih.gov/pubmed/21847114 http://dx.doi.org/10.1038/msb.2011.56

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