Inhibition of the Unfolded Protein Response by Ricin A-Chain Enhances Its Cytotoxicity in Mammalian Cells

Ricin is a highly toxic type II ribosome-inactivating protein that has potential as a biochemical weapon and as the toxic component of immunotoxins. The unfolded protein response (UPR) is a survival response that helps cells to recover from endoplasmic reticulum (ER) stress. Failure to recover from...

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Detalles Bibliográficos
Autores principales: Wang, Chao-Ting, Jetzt, Amanda E., Cheng, Ju-Shun, Cohick, Wendie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202835/
https://www.ncbi.nlm.nih.gov/pubmed/22069719
http://dx.doi.org/10.3390/toxins3050453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202835/
https://www.ncbi.nlm.nih.gov/pubmed/22069719
http://dx.doi.org/10.3390/toxins3050453

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