4-Pyridone-3-carboxamide-1-β-D-ribonucleoside Triphosphate (4PyTP), a Novel NAD(+) Metabolite Accumulating in Erythrocytes of Uremic Children: A Biomarker for a Toxic NAD(+) Analogue in Other Tissues?

We have identified a novel nucleotide, 4-pyridone 3/5-carboxamide ribonucleoside triphosphate (4PyTP), which accumulates in human erythrocytes during renal failure. Using plasma and erythrocyte extracts obtained from children with chronic renal failure we show that the concentration of 4PyTP is incr...

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Detalles Bibliográficos
Autores principales: Synesiou, Elena, Fairbanks, Lynnette D., Simmonds, H. Anne, Slominska, Ewa M., Smolenski, Ryszard T., Carrey, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202843/
https://www.ncbi.nlm.nih.gov/pubmed/22069723
http://dx.doi.org/10.3390/toxins3060520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202843/
https://www.ncbi.nlm.nih.gov/pubmed/22069723
http://dx.doi.org/10.3390/toxins3060520

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