Cargando…

4-Pyridone-3-carboxamide-1-β-D-ribonucleoside Triphosphate (4PyTP), a Novel NAD(+) Metabolite Accumulating in Erythrocytes of Uremic Children: A Biomarker for a Toxic NAD(+) Analogue in Other Tissues?

We have identified a novel nucleotide, 4-pyridone 3/5-carboxamide ribonucleoside triphosphate (4PyTP), which accumulates in human erythrocytes during renal failure. Using plasma and erythrocyte extracts obtained from children with chronic renal failure we show that the concentration of 4PyTP is incr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Synesiou, Elena, Fairbanks, Lynnette D., Simmonds, H. Anne, Slominska, Ewa M., Smolenski, Ryszard T., Carrey, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202843/ https://www.ncbi.nlm.nih.gov/pubmed/22069723 http://dx.doi.org/10.3390/toxins3060520

Ejemplares similares

An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite
por: Mierzejewska, Paulina, et al.
Publicado: (2021)

4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR)—A Novel Oncometabolite Modulating Cancer-Endothelial Interactions in Breast Cancer Metastasis
por: Koszalka, Patrycja, et al.
Publicado: (2022)

N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
por: Lenglet, Aurélie, et al.
Publicado: (2016)

Differences in Extracellular NAD(+) and NMN Metabolism on the Surface of Vascular Endothelial Cells
por: Jablonska, Patrycja, et al.
Publicado: (2022)

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast Saccharomyces cerevisiae
por: Tsai, Hsieh-Chin, et al.
Publicado: (2022)

A Multi‐enzyme Cascade for the Biosynthesis of AICA Ribonucleoside Di‐ and Triphosphate
por: Eltoukhy, Lobna, et al.
Publicado: (2021)

5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells
por: Dembitz, Vilma, et al.
Publicado: (2017)

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
por: Dembitz, Vilma, et al.
Publicado: (2020)

The new insight into extracellular NAD(+) degradation‐the contribution of CD38 and CD73 in calcific aortic valve disease
por: Jablonska, Patrycja, et al.
Publicado: (2021)

“NAD-capQ” detection and quantitation of NAD caps
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2018)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid oxidation in hepatocytes isolated from neonatal piglets
por: Xi, Lin, et al.
Publicado: (2012)

NAD to the rescue
por: Tuma, Rabiya S.
Publicado: (2005)

NAD-seq for profiling the NAD(+) capped transcriptome of Arabidopsis thaliana
por: Yu, Xiang, et al.
Publicado: (2021)

NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health
por: Campagna, Roberto, et al.
Publicado: (2023)

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages
por: Kennedy, Edward M., et al.
Publicado: (2010)

Synthesis of 4-Pyridone-3-sulfate and an improved synthesis of 3-Hydroxy-4-Pyridone
por: Behrman, Edward J
Publicado: (2009)

Quantification of localized NAD(+) changes reveals unique specificity of NAD(+) regulation in the hypothalamus
por: Johnson, Sean, et al.
Publicado: (2023)

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria
por: Rodionova, Irina A., et al.
Publicado: (2014)

Evidence that the nadA motif is a bacterial riboswitch for the ubiquitous enzyme cofactor NAD(+)
por: Malkowski, Sarah N., et al.
Publicado: (2019)

Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA
por: Sharma, Sunny, et al.
Publicado: (2022)

The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae
por: Odoh, Chuks Kenneth, et al.
Publicado: (2022)

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure
por: Buonvicino, Daniela, et al.
Publicado: (2021)

A Mitochondrial Transcription Termination Factor, ZmSmk3, Is Required for nad1 Intron4 and nad4 Intron1 Splicing and Kernel Development in Maize
por: Pan, Zhenyuan, et al.
Publicado: (2019)

NAD (+) biosynthesis, aging, and disease
por: Johnson, Sean, et al.
Publicado: (2018)

Decreased NAD+ in dopaminergic neurons
por: Sison, Samantha L., et al.
Publicado: (2018)

NAD Metabolism in Cancer Therapeutics
por: Yaku, Keisuke, et al.
Publicado: (2018)

Sobriety and Satiety: Is NAD+ the Answer?
por: Braidy, Nady, et al.
Publicado: (2020)

Enzymology of extracellular NAD metabolism
por: Gasparrini, Massimiliano, et al.
Publicado: (2021)

Sources and Importance of Mitochondrial NAD
por: Baur, Joseph, et al.
Publicado: (2020)

The Role of NAD+ in Regenerative Medicine
por: Conlon, Nichola J.
Publicado: (2021)

NAD(+) protects against EAE by regulating CD4(+) T-cell differentiation
por: Tullius, Stefan G., et al.
Publicado: (2014)

In Arabidopsis thaliana mitochondria 5′ end polymorphisms of nad4L-atp4 and nad3-rps12 transcripts are linked to RNA PROCESSING FACTORs 1 and 8
por: Schleicher, Sarah, et al.
Publicado: (2021)

A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs
por: Abele, Florian, et al.
Publicado: (2020)

The Effect of Nicotinamide Riboside, an NAD + Precursor, on Glycolysis and NAD + Salvage Pathway in Alcohol-Stimulated Macrophages
por: Kang, Hyunju, et al.
Publicado: (2022)

The novel E-subgroup pentatricopeptide repeat protein DEK55 is responsible for RNA editing at multiple sites and for the splicing of nad1 and nad4 in maize
por: Ren, Ru Chang, et al.
Publicado: (2020)

The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
por: Kim, Won Gu, et al.
Publicado: (2014)

CapZyme-Seq: A 5′-RNA-Seq Method for Differential Detection and Quantitation of NAD-Capped and Uncapped 5′-Triphosphate RNA
por: Vvedenskaya, Irina O., et al.
Publicado: (2020)

Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry
por: Kong, Ziqing, et al.
Publicado: (2018)

Metabolic flux analysis and the NAD(P)H/NAD(P)(+) ratios in chemostat cultures of Azotobacter vinelandii
por: García, Andres, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kk075emudcllv196pd51oik13g