Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation

Inhibition of AB(5)-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin’s pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system. Effectiv...

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Detalles Bibliográficos
Autores principales: Kitov, Pavel I., Paszkiewicz, Eugenia, Sadowska, Joanna M., Deng, Zhicheng, Ahmed, Marya, Narain, Ravin, Griener, Thomas P., Mulvey, George L., Armstrong, Glen D., Bundle, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202879/
https://www.ncbi.nlm.nih.gov/pubmed/22069757
http://dx.doi.org/10.3390/toxins3091065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202879/
https://www.ncbi.nlm.nih.gov/pubmed/22069757
http://dx.doi.org/10.3390/toxins3091065

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