Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

Glycosyltransferases (GTs) are ubiquitous enzymes that catalyze the assembly of glycoconjugates found throughout all kingdoms of nature. A longstanding problem is the rational design of probes that can be used to manipulate GT activity in cells and tissues. Here we describe the rational design and s...

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Detalles Bibliográficos
Autores principales: Gloster, Tracey M., Zandberg, Wesley F., Heinonen, Julia E., Shen, David L., Deng, Lehua, Vocadlo, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202988/
https://www.ncbi.nlm.nih.gov/pubmed/21258330
http://dx.doi.org/10.1038/nchembio.520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202988/
https://www.ncbi.nlm.nih.gov/pubmed/21258330
http://dx.doi.org/10.1038/nchembio.520

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