Proteasomal Degradation of p53 by Human Papillomavirus E6 Oncoprotein Relies on the Structural Integrity of p53 Core Domain

The E6 oncoprotein produced by high-risk mucosal HPV stimulates ubiquitinylation and proteasome-dependent degradation of the tumour suppressor p53 via formation of a trimeric complex comprising E6, p53, and E6-AP. p53 is also degraded by its main cellular regulator MDM2. The main binding site of p53...

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Detalles Bibliográficos
Autores principales: Bernard, Xavier, Robinson, Philip, Nominé, Yves, Masson, Murielle, Charbonnier, Sebastian, Ramirez-Ramos, Juan Ramon, Deryckere, Francois, Travé, Gilles, Orfanoudakis, Georges
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203139/
https://www.ncbi.nlm.nih.gov/pubmed/22046250
http://dx.doi.org/10.1371/journal.pone.0025981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203139/
https://www.ncbi.nlm.nih.gov/pubmed/22046250
http://dx.doi.org/10.1371/journal.pone.0025981

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