RNA Polymerase II Stalling Promotes Nucleosome Occlusion and pTEFb Recruitment to Drive Immortalization by Epstein-Barr Virus

Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ∼120 kb that is differentially spliced to encode all EBNAs required for immor...

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Detalles Bibliográficos
Autores principales: Palermo, Richard D., Webb, Helen M., West, Michelle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203192/
https://www.ncbi.nlm.nih.gov/pubmed/22046134
http://dx.doi.org/10.1371/journal.ppat.1002334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203192/
https://www.ncbi.nlm.nih.gov/pubmed/22046134
http://dx.doi.org/10.1371/journal.ppat.1002334

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