Methodology and software to detect viral integration site hot-spots

BACKGROUND: Modern gene therapy methods have limited control over where a therapeutic viral vector inserts into the host genome. Vector integration can activate local gene expression, which can cause cancer if the vector inserts near an oncogene. Viral integration hot-spots or 'common insertion...

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Detalles Bibliográficos
Autores principales: Presson, Angela P, Kim, Namshin, Xiaofei, Yan, Chen, Irvin SY, Kim, Sanggu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203353/
https://www.ncbi.nlm.nih.gov/pubmed/21914224
http://dx.doi.org/10.1186/1471-2105-12-367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203353/
https://www.ncbi.nlm.nih.gov/pubmed/21914224
http://dx.doi.org/10.1186/1471-2105-12-367

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